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Article

ABCD1 dysfunction alters white matter microvascular perfusion.

Brain : a journal of neurology - 1 Dec 2017

Lauer Arne, Da Xiao, Hansen Mikkel Bo, Boulouis Gregoire, Ou Yangming, Cai Xuezhu, Liberato Celso Pedrotti Afonso, Kalpathy-Cramer Jayashree, Caruso Paul, Hayden Douglas L, Rost Natalia, Mouridsen Kim, Eichler Florian S, Rosen Bruce, Musolino Patricia L

Abstract excerpt

Cerebral X-linked adrenoleukodystrophy is a devastating neurodegenerative disorder caused by mutations in the ABCD1 gene, which lead to a rapidly progressive cerebral inflammatory demyelination in up to 60% of affected males. Selective brain endothelial dysfunction and increased permeability of the blood-brain barrier suggest that white matter microvascular dysfunction contributes to the conversion to cerebral...

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Source

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Identifiers

PMID: 29136088
DOI: 10.1093/brain/awx262
PMCID: PMC5841142

Genes

ABCD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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