Article
HBsAg mRNA degradation induced by a dihydroquinolizinone compound depends on the HBV posttranscriptional regulatory element.
Antiviral research - 1 Jan 2018
Zhou Tianlun, Block Timothy, Liu Fei, Kondratowicz Andrew S, Sun Liren, Rawat Siddhartha, Branson Jeffrey, Guo Fang, Steuer Holly Micolochick, Liang Hongyan, Bailey Lauren, Moore Chris, Wang Xiaohe, Cuconatti Andy, Gao Min, Lee Amy C H, Harasym Troy, Chiu Tim, Gotchev Dimitar, Dorsey Bruce, Rijnbrand Rene, Sofia Michael J
Abstract excerpt
In pursuit of novel therapeutics targeting the hepatitis B virus (HBV) infection, we evaluated a dihydroquinolizinone compound (DHQ-1) that in the nanomolar range reduced the production of virion and surface protein (HBsAg) in tissue culture. This compound also showed broad HBV genotype coverage, but was inactive against a panel of DNA and RNA viruses of other species. Oral administration of DHQ-1 in the AAV-HBV...
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