Article
An NRG Oncology/GOG study of molecular classification for risk prediction in endometrioid endometrial cancer.
Gynecologic oncology - 1 Jan 2018
Cosgrove Casey M, Tritchler David L, Cohn David E, Mutch David G, Rush Craig M, Lankes Heather A, Creasman William T, Miller David S, Ramirez Nilsa C, Geller Melissa A, Powell Matthew A, Backes Floor J, Landrum Lisa M, Timmers Cynthia, Suarez Adrian A, Zaino Richard J, Pearl Michael L, DiSilvestro Paul A, Lele Shashikant B, Goodfellow Paul J
Abstract excerpt
OBJECTIVES: The purpose of this study was to assess the prognostic significance of a simplified, clinically accessible classification system for endometrioid endometrial cancers combining Lynch syndrome screening and molecular risk stratification. METHODS: Tumors from NRG/GOG GOG210 were evaluated for mismatch repair defects (MSI, MMR IHC, and MLH1 methylation), POLE mutations, and loss of heterozygosity. TP53...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.