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Article

SATB1 Conditional Knockout Results in Sjögren's Syndrome in Mice.

Journal of immunology (Baltimore, Md. : 1950) - 15 Dec 2017

Tanaka Yuriko, Sotome Takehiko, Inoue Akiko, Mukozu Takanori, Kuwabara Taku, Mikami Tetuo, Kowhi-Shigematsu Terumi, Kondo Motonari

Abstract excerpt

Sjögren's syndrome (SS) is an autoimmune disease in which exocrine tissues are affected by cellular and humoral immunity. As a result, the salivary and lacrimal glands of patients with SS are damaged, leading to xerostomia (dry mouth) and keratoconjunctivitis sicca (dry eyes). Because experimental approaches to investigate SS pathogenesis in human patients are limited, development of a mouse model is...

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Source

Identifiers

PMID: 29127143
DOI: 10.4049/jimmunol.1700550

Genes

SATB1
SSB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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