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Article

Type I interferon receptor deficiency prevents murine Sjogren's syndrome.

Journal of dental research - 1 May 2013

Szczerba B M, Rybakowska P D, Dey P, Payerhin K M, Peck A B, Bagavant H, Deshmukh U S

Abstract excerpt

In Sjögren's Syndrome (SS), inherent glandular defects, autoimmunity, and mononuclear cell infiltration within the salivary glands cause reduced salivation leading to xerostomia. Excessive production of type I interferons (IFN), triggered by environmental and genetic factors, is considered pathogenic in this disorder. However, whether type I IFN production is causative or an outcome of the disease process is not...

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Identifiers

PMID: 23533183
DOI: 10.1177/0022034513483315
PMCID: PMC3627507

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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