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Article

Excluding Lynch syndrome in a female patient with metachronous DNA mismatch repair deficient colon- and ovarian cancer.

Familial cancer - 1 Jul 2018

Crobach Stijn, Jansen Anne M L, Ligtenberg Marjolein J L, Koopmans Marije, Nielsen Maartje, Hes Frederik J, Wijnen Juul T, Dinjens Winand N M, van Wezel Tom, Morreau Hans

Abstract excerpt

Patients synchronously or metachronously presenting with ovarian and colon cancer can pose diagnostic challenges. A primary colon carcinoma can metastasize to one or both ovaries, two independent primary tumors can arise or an ovarian carcinoma can metastasize to the colon. Clinical and immunohistochemical characterization can aid the diagnosis. Recently, we reported that in difficult cases finding pathogenic APC...

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Topics

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Share to Colonic Neoplasms
Share to Colorectal Neoplasms, Hereditary Nonpolyposis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Mismatch Repair

Share to CTNNB1 gene

Share to PMS2 gene

Share to Genetic Predisposition to Disease

Share to Neoplasms, Multiple Primary

Share to Ovarian Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 29124495
DOI: 10.1007/s10689-017-0055-1
PMCID: PMC5999177

Genes

MLH1
APC
CTNNB1
PMS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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