Article
Metagenomic deep sequencing of aqueous fluid detects intraocular lymphomas.
The British journal of ophthalmology - 1 Jan 2018
Gonzales John, Doan Thuy, Shantha Jessica G, Bloomer Michele, Wilson Michael R, DeRisi Joseph L, Acharya Nisha
Abstract excerpt
INTRODUCTION: Currently, the detection of pathogens or mutations associated with intraocular lymphomas heavily relies on prespecified, directed PCRs. With metagenomic deep sequencing (MDS), an unbiased high-throughput sequencing approach, all pathogens as well as all mutations present in the host's genome can be detected in the same small amount of ocular fluid. METHODS: In this cross-sectional case series,...
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