Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Alanine scanning mutagenesis of SP70 epitope in characterizing species‑specific antibodies induced by enterovirus 71‑based antigens.

Molecular medicine reports - 1 Jan 2018

Gao Meng, Zhang Feng, Zhu Yun, Gao Limei, Jiang Yunshui, Luo Yongneng, Zhuang Fangchang, Mao Zian, Mao Jiangsen

Abstract excerpt

The enterovirus 71 (EV71) SP70 epitope, derived from amino acids 208‑222 of VP1, is a neutralizing epitope. The present study aimed to assess the inter‑species differences of the antibodies induced by EV71‑based antigens in responses to SP70 mutant peptides. BALB/c mice and Lou/C rats were immunized with EV71 SP70. Monoclonal antibodies (Mabs) were produced by hybridoma clones. Serum polyclonal antibodies (Pabs)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alanine
Share to Antibodies, Neutralizing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Antibodies, Viral

Share to Antibody Specificity

Share to Antigens, Viral

Share to Enterovirus A, Human

Share to Neutralization Tests

Share to Vero Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 29115505
DOI: 10.3892/mmr.2017.7992
PMCID: PMC5780067

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Alanine scanning mutagenesis of SP70 epitope in characterizing species‑specific antibodies induced by enterovirus 71‑based antigens.PMID 29115505Read ↗

Chimeric Virus-Like Particle Vaccines Displaying Conserved Enterovirus 71 Epitopes Elicit Protective Neutralizing Antibodies in Mice through Divergent MechanismsSemantic proximity Read ↗

Cross-reactive neutralizing antibody responses to enterovirus 71 infections in young children: implications for vaccine development.Semantic proximity Read ↗

Establishment of an animal challenge model as a potency assay for an inactivated Enterovirus Type 71 vaccine.Semantic proximity Read ↗

Monoclonal antibodies for diagnosis of enterovirus 71.Semantic proximity Read ↗

Characterization and specificity of the linear epitope of the enterovirus 71 VP2 protein.Semantic proximity Read ↗

Antigenic analysis of divergent genotypes human Enterovirus 71 viruses by a panel of neutralizing monoclonal antibodies: current genotyping of EV71 does not reflect their antigenicity.Semantic proximity Read ↗

Antigenicity, animal protective effect and genetic characteristics of candidate vaccine strains of enterovirus 71Semantic proximity Read ↗

Neutralizing antibodies induced by recombinant virus-like particles of enterovirus 71 genotype C4 inhibit infection at pre- and post-attachment steps.Semantic proximity Read ↗

Cross-Antigenicity between EV71 Sub-Genotypes: Implications for Vaccine Efficacy.Semantic proximity Read ↗

TAK - 021, an inactivated Enterovirus 71 vaccine candidate, provides cross-protection against heterologous sub-genogroups in human scavenger receptor B2 transgenic mice.Semantic proximity Read ↗

Development of a high-growth enterovirus 71 vaccine candidate inducing cross-reactive neutralizing antibody responses.Semantic proximity Read ↗

Japanese encephalitis virus replicon-based vaccine expressing enterovirus-71 epitope confers dual protection from lethal challengesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.