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Article

Establishment of an animal challenge model as a potency assay for an inactivated Enterovirus Type 71 vaccine.

Biologicals : journal of the International Association of Biological Standardization - 1 Jul 2016

Wang Kun-Teng, Lin Shih-Jie, Wang Hsiu-Chi, Chen Pin-Chun, Lin Jiao-Jung, Chiang Jen-Ron, Chang Chao-Liang, Shih Daniel Yang-Chih, Lo Chi-Fang, Wang Der-Yuan

Abstract excerpt

Enterovirus 71 (EV71) belongs to the Enterovirus genus of the Picornaviridae family, and its occurrence in Asia is associated with hand-foot-and-mouth disease (HFMD), leading to death in some cases, in young children. An effective EV71 vaccine is therefore urgently needed. In this study, we established a two-step EV71 vaccine potency model. Intraperitoneal injections in 2-day-old suckling mice were used to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27068365
DOI: 10.1016/j.biologicals.2016.01.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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