Article
Cross-Antigenicity between EV71 Sub-Genotypes: Implications for Vaccine Efficacy.
Viruses - 21 Apr 2021
Liu Pei, Yuan Yadi, Cui Bopei, Huo Yaqian, Bian Lianlian, Chen Lei, Liu Siyuan, Wang Chenfei, Xu Yingzhi, Tedcastle Alison, Gao Fan, Mao Qunying, Martin Javier, Liang Zhenglun
Abstract excerpt
Enterovirus A-71 (EV71) is a global, highly contagkkious pathogen responsible for severe cases of hand-food-mouth-disease (HFMD). The use of vaccines eliciting cross neutralizing antibodies (NTAbs) against the different circulating EV71 sub-genotypes is important for preventing HFMD outbreaks. Here, we tested the cross-neutralizing activities induced by EV71 genotype/sub-genotype A, B0-B4, C1, C2, C4, and C5...
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