Article
Directed evolution of SecB chaperones toward toxin-antitoxin systems.
Proceedings of the National Academy of Sciences of the United States of America - 21 Nov 2017
Sala Ambre Julie, Bordes Patricia, Ayala Sara, Slama Nawel, Tranier Samuel, Coddeville Michèle, Cirinesi Anne-Marie, Castanié-Cornet Marie-Pierre, Mourey Lionel, Genevaux Pierre
Abstract excerpt
SecB chaperones assist protein export in bacteria. However, certain SecB family members have diverged to become specialized toward the control of toxin-antitoxin (TA) systems known to promote bacterial adaptation to stress and persistence. In such tripartite TA-chaperone (TAC) systems, the chaperone was shown to assist folding and to prevent degradation of its cognate antitoxin, thus facilitating inhibition of...
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