Article
Twin-arginine translocase mutations that suppress folding quality control and permit export of misfolded substrate proteins.
Proceedings of the National Academy of Sciences of the United States of America - 14 Aug 2012
Rocco Mark A, Waraho-Zhmayev Dujduan, DeLisa Matthew P
Abstract excerpt
The bacterial twin-arginine translocation (Tat) pathway facilitates the transport of correctly folded proteins across the tightly sealed cytoplasmic membrane. Here, we report the isolation and characterization of suppressor mutations in the Tat translocase that allow export of misfolded proteins, which form structures that are not normally tolerated by the wild-type translocase. Selection of suppressors was...
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