SecB-like chaperone controls a toxin–antitoxin stress-responsive system in <i>Mycobacterium tuberculosis</i>

Abstract excerpt

A major step in the biogenesis of newly synthesized precursor proteins in bacteria is their targeting to the Sec translocon at the inner membrane. In gram-negative bacteria, the chaperone SecB binds nonnative forms of precursors and specifically transfers them to the SecA motor component of the translocase, thus facilitating their export. The major human pathogen Mycobacterium tuberculosis is an unusual...

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