Article
The nonstructural proteins of Pneumoviruses are remarkably distinct in substrate diversity and specificity.
Virology journal - 6 Nov 2017
Ribaudo Michael, Barik Sailen
Abstract excerpt
BACKGROUND: Interferon (IFN) inhibits viruses by inducing several hundred cellular genes, aptly named 'interferon (IFN)-stimulated genes' (ISGs). The only two RNA viruses of the Pneumovirus genus of the Paramyxoviridae family, namely Respiratory Syncytial Virus (RSV) and Pneumonia Virus of Mice (PVM), each encode two nonstructural (NS) proteins that share no sequence similarity but yet suppress IFN. Since...
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