Article
Phenotype standardization for immune-mediated drug-induced skin injury.
Clinical pharmacology and therapeutics - 1 Jun 2011
Pirmohamed M, Friedmann P S, Molokhia M, Loke Y K, Smith C, Phillips E, La Grenade L, Carleton B, Papaluca-Amati M, Demoly P, Shear N H
Abstract excerpt
Advances in genetic research and molecular biology techniques have made it possible to begin to characterize the underlying genetic factors that predispose patients to serious forms of drug-induced skin injury (DISI). To facilitate research in this area, we have set out standardized phenotypic definitions for (i) Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN), (ii) acute generalized exanthematous...
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