Article
Analysis of CTLA-4+49A/G gene polymorphism in cases with leprosy of Azerbaijan, Northwest Iran.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Jan 2018
Almasi Shohreh, Aliparasti Mohammad Reza, Naghili Behrouz, Yeganeh Khalil, Rahnama Badrossadat, Tavanafar Fatemeh, Hazhir Karzar Bita, Amini Khiabani Syamak, Naghili Arman, Babaloo Zohreh
Abstract excerpt
Leprosy, which is developed by the obligate intracellular Mycobacterium leprae (ML); has different manifestations, associated with the host immune responses. The protective immune response against ML includes T-cell-mediated immunity. The CTLA-4 has a great impact as a negative regulator of the immune response and maintenance of peripheral tolerance. This study analyzed the relationship between CTLA-4+49A/G gene...
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