Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Assessment of ATP8B1 Deficiency in Pediatric Patients With Cholestasis Using Peripheral Blood Monocyte-Derived Macrophages.

EBioMedicine - 1 Jan 2018

Hayashi Hisamitsu, Naoi Sotaro, Togawa Takao, Hirose Yu, Kondou Hiroki, Hasegawa Yasuhiro, Abukawa Daiki, Sasaki Mika, Muroya Koji, Watanabe Satoshi, Nakano Satoshi, Minowa Kei, Inui Ayano, Fukuda Akinari, Kasahara Mureo, Nagasaka Hironori, Bessho Kazuhiko, Suzuki Mitsuyoshi, Kusuhara Hiroyuki

Abstract excerpt

Progressive familial intrahepatic cholestasis type 1 (PFIC1), a rare inherited recessive disease resulting from a genetic deficiency in ATP8B1, progresses to liver failure. Because of the difficulty of discriminating PFIC1 from other subtypes of PFIC based on its clinical and histological features and genome sequencing, an alternative method for diagnosing PFIC1 is desirable. Herein, we analyzed human peripheral...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Triphosphatases
Share to Cholestasis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to gamma-Glutamyltransferase

Share to Interleukin-10

Share to Macrophages

Share to Monocytes

Share to Mutagenesis

Share to STAT3 Transcription Factor

Source

Open in PubMed Open full text

Identifiers

PMID: 29104077
DOI: 10.1016/j.ebiom.2017.10.007
PMCID: PMC5828058

Genes

STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Assessment of ATP8B1 Deficiency in Pediatric Patients With Cholestasis Using Peripheral Blood Monocyte-Derived Macrophages.PMID 29104077Read ↗

Assessment of Adenosine Triphosphatase Phospholipid Transporting 8B1 (ATP8B1) Function in Patients With Cholestasis With ATP8B1 Deficiency by Using Peripheral Blood Monocyte-Derived Macrophages.Semantic proximity Read ↗

Intrahepatic cholestasis in two omani siblings associated with a novel homozygous ATP8B1 mutation, c.379C>G (p.L127V).Semantic proximity Read ↗

Transcriptional profiling of pediatric cholestatic livers identifies three distinct macrophage populationsSemantic proximity Read ↗

Characterization of mutations in ATP8B1 associated with hereditary cholestasis.Semantic proximity Read ↗

ABCB4 Mutations in Adults Cause a Spectrum Cholestatic Disorder Histologically Distinct from Other Biliary Disease.Semantic proximity Read ↗

Novel ATP8B1 mutation in an adult male with progressive familial intrahepatic cholestasis.Semantic proximity Read ↗

Functional analysis and transcriptomic profiling of iPSC-derived macrophages and their application in modeling Mendelian disease.Semantic proximity Read ↗

FIC1 and BSEP defects in Taiwanese patients with chronic intrahepatic cholestasis with low gamma-glutamyltranspeptidase levels.Semantic proximity Read ↗

ATP-binding cassette transporter A1 (ABCA1) in macrophages: a dual function in inflammation and lipid metabolism?Semantic proximity Read ↗

Folding Defects in P-Type Atp 8B1 Associated With Hereditary Cholestasis Are Ameliorated by 4-PhenylbutyrateSemantic proximity Read ↗

Soluble CD83 modulates human-monocyte-derived macrophages toward alternative phenotype, function, and metabolism.Semantic proximity Read ↗

ABCA1 Exerts Tumor-Suppressor Function in Myeloproliferative NeoplasmsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.