Article
Neuroglobin-deficiency exacerbates Hif1A and c-FOS response, but does not affect neuronal survival during severe hypoxia in vivo.
PloS one - 1 Jan 2011
Hundahl Christian Ansgar, Luuk Hendrik, Ilmjärv Sten, Falktoft Birgitte, Raida Zindy, Vikesaa Jonas, Friis-Hansen Lennart, Hay-Schmidt Anders
Abstract excerpt
BACKGROUND: Neuroglobin (Ngb), a neuron-specific globin that binds oxygen in vitro, has been proposed to play a key role in neuronal survival following hypoxic and ischemic insults in the brain. Here we address whether Ngb is required for neuronal survival following acute and prolonged hypoxia in mice genetically Ngb-deficient (Ngb-null). Further, to evaluate whether the lack of Ngb has an effect on...
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