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Article

Distal mutation modulates the heme sliding in mouse neuroglobin investigated by molecular dynamics simulation.

Proteins - 1 Jan 2011

Xu Jia, Yin Guowei, Du Weihong

Abstract excerpt

Neuroglobin (Ngb), a hexa-coordinated hemoprotein primarily expressed in the brain and retina, is thought to be involved in neuroprotection and signal transduction. Ngb can reversibly bind small ligands such as O₂ and CO to the heme iron by replacing the distal histidine which is bound to the iron as the endogenous ligand. In this work, molecular dynamics (MD) simulations were performed to investigate the...

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PMID: 21058400
DOI: 10.1002/prot.22872

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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