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Article

Virtual Sorting Has a Distinctive Advantage in Identification of Anticorrelated Genes and Further Negative Regulators of Immune Cell Subpopulations.

Journal of immunology (Baltimore, Md. : 1950) - 15 Dec 2017

Wang Pingzhang, Han Wenling, Ma Dalong

Abstract excerpt

Immune cells are highly plastic in both gene expression and cell phenotype. We have established a method of gene expressional plasticity and virtual sorting to evaluate immune cell subpopulations and their characteristic genes in human CD4+ T cells. In this study, we continued to investigate the informatics mechanism on the effectiveness of virtual sorting. We found that virtual sorting had an overall positive...

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PMID: 29093063
DOI: 10.4049/jimmunol.1700946

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