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A novel graph-based k-partitioning approach improves the detection of gene-gene correlations by single-cell RNA sequencing

7 Jan 2022

Abstract excerpt

BACKGROUND: Gene expression is regulated by transcription factors, cofactors, and epigenetic mechanisms. Coexpressed genes indicate similar functional categories and gene networks. Detecting gene-gene coexpression is important for understanding the underlying mechanisms of cellular function and human diseases. A common practice of identifying coexpressed genes is to test the correlation of expression in a set of...

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PMID: 34996359
DOI: 10.1186/s12864-021-08235-4

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