Article
Novel SEC61G-EGFR Fusion Gene in Pediatric Ependymomas Discovered by Clonal Expansion of Stem Cells in Absence of Exogenous Mitogens.
Cancer research - 1 Nov 2017
Servidei Tiziana, Meco Daniela, Muto Valentina, Bruselles Alessandro, Ciolfi Andrea, Trivieri Nadia, Lucchini Matteo, Morosetti Roberta, Mirabella Massimiliano, Martini Maurizio, Caldarelli Massimo, Lasorella Anna, Tartaglia Marco, Riccardi Riccardo
Abstract excerpt
The basis for molecular and cellular heterogeneity in ependymomas of the central nervous system is not understood. This study suggests a basis for this phenomenon in the selection for mitogen-independent (MI) stem-like cells with impaired proliferation but increased intracranial tumorigenicity. MI ependymoma cell lines created by selection for EGF/FGF2-independent proliferation exhibited constitutive activation...
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