Article
Pediatric brain tumor cancer stem cells: cell cycle dynamics, DNA repair, and etoposide extrusion.
Neuro-oncology - 1 Jan 2011
Hussein Deema, Punjaruk Wiyada, Storer Lisa C D, Shaw Lucy, Othman Ramadhan, Ottoman Ramadan, Peet Andrew, Miller Suzanne, Bandopadhyay Gagori, Heath Rachel, Kumari Rajendra, Bowman Karen J, Braker Paul, Rahman Ruman, Jones George D D, Watson Susan, Lowe James, Kerr Ian D, Grundy Richard G, Coyle Beth
Abstract excerpt
Reliable model systems are needed to elucidate the role cancer stem cells (CSCs) play in pediatric brain tumor drug resistance. The majority of studies to date have focused on clinically distinct adult tumors and restricted tumor types. Here, the CSC component of 7 newly established primary pediatric cell lines (2 ependymomas, 2 medulloblastomas, 2 gliomas, and a CNS primitive neuroectodermal tumor) was...
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