Article
Candidate genes on chromosome 9q33-34 involved in the progression of childhood ependymomas.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 10 Apr 2009
Puget Stéphanie, Grill Jacques, Valent Alexander, Bieche Ivan, Dantas-Barbosa Carmela, Kauffmann Audrey, Dessen Philippe, Lacroix Ludovic, Geoerger Birgit, Job Bastien, Dirven Clemens, Varlet Pascale, Peyre Mathieu, Dirks Peter B, Sainte-Rose Christian, Vassal Gilles
Abstract excerpt
PURPOSE: The molecular pathogenesis of pediatric ependymoma remains unclear. Our study was designed to identify genetic changes implicated in ependymoma progression. PATIENTS AND METHODS: We characterized 59 ependymoma samples (33 at diagnosis and 26 at relapse) using array-comparative genomic hybridization (aCGH). Specific chromosomal imbalances were confirmed by fluorescent in situ hybridization, and candidate...
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