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Article

Optimizing and accelerating the assignation of lineages in Mycobacterium tuberculosis using novel alternative single-tube assays.

PloS one - 1 Jan 2017

Carcelén María, Abascal Estefanía, Herranz Marta, Santantón Sheila, Zenteno Roberto, Ruiz Serrano María Jesús, Bouza Emilio, Pérez-Lago Laura, García-de-Viedma Darío

Abstract excerpt

The assignation of lineages in Mycobacterium tuberculosis (MTB) provides valuable information for evolutionary and phylogeographic studies and makes for more accurate knowledge of the distribution of this pathogen worldwide. Differences in virulence have also been found for certain lineages. MTB isolates were initially assigned to lineages based on data obtained from genotyping techniques, such as spoligotyping...

Topics

Genes, Bacterial
Multiplex Polymerase Chain Reaction
Mycobacterium tuberculosis
Polymorphism, Single Nucleotide
Virulence

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 29091913
DOI: 10.1371/journal.pone.0186956
PMCID: PMC5665510

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