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Structural and functional analysis of natural capsid variants reveals sialic-acid independent entry of BK polyomavirus

2022-07-14

Abstract excerpt

BK Polyomavirus (BKPyV) is an opportunistic pathogen that causes nephropathy in kidney transplant recipients. The BKPyV major capsid protein, VP1, engages gangliosides, lipid-linked sialylated glycans at the cell surface, to gain entry into cells. Here, we characterise the influence of VP1 mutations observed in patients with persistent post-transplant BKPyV replication on ganglioside binding, VP1 protein structure...

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Identifiers and source

Literature Corpus work
7632d6eb-9146-5463-92cc-f47a65a096b5
DOI
10.1101/2022.07.13.499703
Open publication

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Structural and functional analysis of natural capsid variants reveals sialic-acid independent entry of BK polyomavirusDOI 10.1101/2022.07.13.499703
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