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Article

Male fertility restored by transplanting primordial germ cells into testes: a new way towards efficient transgenesis in chicken.

Scientific reports - 27 Oct 2017

Trefil Pavel, Aumann Dorothea, Koslová Anna, Mucksová Jitka, Benešová Barbora, Kalina Jiří, Wurmser Christine, Fries Ruedi, Elleder Daniel, Schusser Benjamin, Hejnar Jiří

Abstract excerpt

The ongoing progress in primordial germ cell derivation and cultivation is opening new ways in reproductive biotechnology. This study tested whether functional sperm cells can be matured from genetically manipulated primordial germ cells after transplantation in adult testes and used to restore fertility. We show that spermatogenesis can be restored after mCherry-expressing or GFP-expressing primordial germ cells...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29079843
DOI: 10.1038/s41598-017-14475-w
PMCID: PMC5660165

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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