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Article

Structural insights into binding of STAC proteins to voltage-gated calcium channels.

Proceedings of the National Academy of Sciences of the United States of America - 7 Nov 2017

Wong King Yuen Siobhan M, Campiglio Marta, Tung Ching-Chieh, Flucher Bernhard E, Van Petegem Filip

Abstract excerpt

Excitation-contraction (EC) coupling in skeletal muscle requires functional and mechanical coupling between L-type voltage-gated calcium channels (CaV1.1) and the ryanodine receptor (RyR1). Recently, STAC3 was identified as an essential protein for EC coupling and is part of a group of three proteins that can bind and modulate L-type voltage-gated calcium channels. Here, we report crystal structures of tandem-SH3...

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Source

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Identifiers

PMID: 29078335
DOI: 10.1073/pnas.1708852114
PMCID: PMC5692558

Genes

STAC3
STAC
STAC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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