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Deregulated expression and activity of Farnesyl Diphosphate Synthase (FDPS) in Glioblastoma

20 Oct 2017

Abstract excerpt

Glioblastoma (GBM), the most aggressive brain cancer, is highly dependent on the mevalonate (MVA) pathway for the synthesis of lipid moieties critical for cell proliferation but the function and regulation of key intermediate enzymes like farnesyl-diphosphate synthase (FDPS), up to now, remained unknown. A deregulated expression and activity of FDPS was the central research idea of the present study. FDPS mRNA,...

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PMID: 29075041
DOI: 10.1038/s41598-017-14495-6

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