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Article

Single-cell transcriptomic analysis identifies downregulated phosphodiesterase 8B as a novel oncogene in IDH-mutant glioma.

Frontiers in immunology - 1 Jan 2024

He Zongze, Peng Yu, Wang Duo, Yang Chen, Zhou Chengzhi, Gong Bo, Song Siyuan, Wang Yi

Abstract excerpt

Introduction: Glioma, a prevalent and deadly brain tumor, is marked by significant cellular heterogeneity and metabolic alterations. However, the comprehensive cell-of-origin and metabolic landscape in high-grade (Glioblastoma Multiforme, WHO grade IV) and low-grade (Oligoastrocytoma, WHO grade II) gliomas remains elusive. Methods: In this study, we undertook single-cell transcriptome sequencing of these glioma...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38989284
DOI: 10.3389/fimmu.2024.1427200
PMCID: PMC11233524

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