Article
Synergism of antifungal activity between mitochondrial respiration inhibitors and kojic acid.
Molecules (Basel, Switzerland) - 25 Jan 2013
Kim Jong H, Campbell Bruce C, Chan Kathleen L, Mahoney Noreen, Haff Ronald P
Abstract excerpt
Co-application of certain types of compounds to conventional antimicrobial drugs can enhance the efficacy of the drugs through a process termed chemosensitization. We show that kojic acid (KA), a natural pyrone, is a potent chemosensitizing agent of complex III inhibitors disrupting the mitochondrial respiratory chain in fungi. Addition of KA greatly lowered the minimum inhibitory concentrations of complex III...
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