Renalase rs2296545 variant improve hypertension susceptibility by modifying binding affinity to catecholamines in obstructive sleep apnea.

doi:10.1038/s41440-024-01850-0

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Renalase rs2296545 variant improve hypertension susceptibility by modifying binding affinity to catecholamines in obstructive sleep apnea.

Hypertension research : official journal of the Japanese Society of Hypertension - 1 Nov 2024

Shen Hangdong, Yang Jundong, Xue Wenjun, Wei Zhicheng, Li Lilin, Guan Jian, Li Xinyi, Wu Xiaolin

Abstract excerpt

Obstructive sleep apnea (OSA), a condition often linked with hypertension, has an undefined relationship with renalase, a protein known for regulating blood pressure. This study aimed to investigate the relationship between serum renalase levels as well as renalase functional single nucleotide polymorphism (SNP) rs2296545 variant and hypertension in a Han Chinese OSA population. 126 subjects underwent serum...

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PMID: 39232213
DOI: 10.1038/s41440-024-01850-0
PMCID: PMC11534681

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