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Article

Analytical Validation of a Next-Generation Sequencing Assay to Monitor Immune Responses in Solid Tumors.

The Journal of molecular diagnostics : JMD - 1 Jan 2018

Conroy Jeffrey M, Pabla Sarabjot, Glenn Sean T, Burgher Blake, Nesline Mary, Papanicolau-Sengos Antonios, Andreas Jonathan, Giamo Vincent, Lenzo Felicia L, Hyland Fiona C L, Omilian Angela, Bshara Wiam, Qin Moachun, He Ji, Puzanov Igor, Ernstoff Marc S, Gardner Mark, Galluzzi Lorenzo, Morrison Carl

Abstract excerpt

We have developed a next-generation sequencing assay to quantify biomarkers of the host immune response in formalin-fixed, paraffin-embedded (FFPE) tumor specimens. This assay aims to provide clinicians with a comprehensive characterization of the immunologic tumor microenvironment as a guide for therapeutic decisions on patients with solid tumors. The assay relies on RNA-sequencing (seq) to semiquantitatively...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29061374
DOI: 10.1016/j.jmoldx.2017.10.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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