Development and validation of a multigene variant profiling assay to guide targeted and immuno therapy selection in solid tumors.

doi:10.1371/journal.pone.0246048

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Article

Development and validation of a multigene variant profiling assay to guide targeted and immuno therapy selection in solid tumors.

PloS one - 1 Jan 2021

Akolkar Dadasaheb, Patil Darshana, Srivastava Navin, Patil Revati, Datta Vineet, Apurwa Sachin, Yashwante Nitin, Dhasarathan Raja, Gosavi Rahul, John Jinumary, Khan Shabishta, Jadhav Ninad, Mene Priti, Ahire Dhanashri, Pawar Sushant, Bodke Harshal, Sahoo Subhraline, Nile Arun, Saindane Dinesh, Darokar Harshal, Devhare Pradip, Srinivasan Ajay, Datar Rajan

Abstract excerpt

We present data on analytical validation of the multigene variant profiling assay (CellDx) to provide actionable indications for selection of targeted and immune checkpoint inhibitor (ICI) therapy in solid tumors. CellDx includes Next Generation Sequencing (NGS) profiling of gene variants in a targeted 452-gene panel as well as status of total Tumor Mutation Burden (TMB), Microsatellite instability (MSI),...

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PMID: 33556149
DOI: 10.1371/journal.pone.0246048
PMCID: PMC7870065

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