Article
Whole transcriptome analysis of human erythropoietic cells during ontogenesis suggests a role of VEGFA gene as modulator of fetal hemoglobin and pharmacogenomic biomarker of treatment response to hydroxyurea in β-type hemoglobinopathy patients.
Human genomics - 23 Oct 2017
Chondrou Vasiliki, Kolovos Petros, Sgourou Argyro, Kourakli Alexandra, Pavlidaki Alexia, Kastrinou Vlasia, John Anne, Symeonidis Argiris, Ali Bassam R, Papachatzopoulou Adamantia, Katsila Theodora, Patrinos George P
Abstract excerpt
BACKGROUND: Human erythropoiesis is characterized by distinct gene expression profiles at various developmental stages. Previous studies suggest that fetal-to-adult hemoglobin switch is regulated by a complex mechanism, in which many key players still remain unknown. Here, we report our findings from whole transcriptome analysis of erythroid cells, isolated from erythroid tissues at various developmental stages...
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