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Recent Approaches for Manipulating Globin Gene Expression in Treating Hemoglobinopathies

2 Aug 2021

Abstract excerpt

Tissue oxygenation throughout life depends on the activity of hemoglobin (Hb) one of the hemeproteins that binds oxygen in the lungs and secures its delivery throughout the body. Hb is composed of four monomers encoded by eight different genes the expression of which is tightly regulated during development, resulting in the formation of distinct hemoglobin tetramers in each developmental stage. Mutations that...

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PMID: 34713248
DOI: 10.3389/fgeed.2021.618111

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