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Article

Targeting MDMX for Cancer Therapy: Rationale, Strategies, and Challenges

5 Aug 2020

Abstract excerpt

The oncogene MDMX, also known as MDM4 is a critical negative regulator of the tumor suppressor p53 and has been implicated in the initiation and progression of human cancers. Increasing evidence indicates that MDMX is often amplified and highly expressed in human cancers, promotes cancer cell growth, and inhibits apoptosis by dampening p53-mediated transcription of its target genes. Inhibiting MDMX-p53...

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PMID: 32850448
DOI: 10.3389/fonc.2020.01389

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