Article
Search for Genetic Modifiers of PSC: Time to Increase the Number of Needles in the Haystack.
Annals of hepatology - 1 Jan 2000
Krawczyk Marcin, Lammert Frank
Abstract excerpt
Primary sclerosing cholangitis (PSC) belongs to the most obscure liver diseases. Patients with progressive PSC require liver transplantation as only therapeutic option. Previously several HLA- and non-HLA-associated PSC risk variants have been discovered, however their involvement in the development of PSC seems to be minor in comparison to environmental determinants. Lately, variant rs853974 at the RSPO3 gene...
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