Tris (2-chloroethyl) phosphate induces senescence-like phenotype of hepatocytes via the p21Waf1/Cip1-Rb pathway in a p53-independent manner.

doi:10.1016/j.etap.2017.08.028

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Tris (2-chloroethyl) phosphate induces senescence-like phenotype of hepatocytes via the p21Waf1/Cip1-Rb pathway in a p53-independent manner.

Environmental toxicology and pharmacology - 1 Dec 2017

Zhang Wenjuan, Zhang Youjian, Hou Jian, Xu Tian, Yin Wenjun, Xiong Wei, Lu Wenhong, Zheng Hongyan, Chen Jun, Yuan Jing

Abstract excerpt

Tris (2-chloroethyl) phosphate (TCEP) has been widely used as a plasticizer and flame retardant. TCEP as a potential carcinogen is often detected in the occupational and nature environments. To investigate effects of TCEP on human hepatocytes, we assessed cell growth rate, cellular membrane integrity, senescence-associated β-galactosidase (SA-β-Gal) activity and analyzed expression of regulators involved in the...

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Tris (2-chloroethyl) phosphate induces senescence-like phenotype of hepatocytes via the p21Waf1/Cip1-Rb pathway in a p53-independent manner.

Abstract excerpt

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