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Article

Genetic evidence of a causal effect of insulin resistance on branched-chain amino acid levels.

Diabetologia - 1 May 2017

Mahendran Yuvaraj, Jonsson Anna, Have Christian T, Allin Kristine H, Witte Daniel R, Jørgensen Marit E, Grarup Niels, Pedersen Oluf, Kilpeläinen Tuomas O, Hansen Torben

Abstract excerpt

AIMS/HYPOTHESIS: Fasting plasma levels of branched-chain amino acids (BCAAs) are associated with insulin resistance, but it remains unclear whether there is a causal relation between the two. We aimed to disentangle the causal relations by performing a Mendelian randomisation study using genetic variants associated with circulating BCAA levels and insulin resistance as instrumental variables. METHODS: We measured...

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PMID: 28184960
DOI: 10.1007/s00125-017-4222-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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