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Article

Knockout of maternal CD163 protects fetuses from infection with porcine reproductive and respiratory syndrome virus (PRRSV).

Scientific reports - 17 Oct 2017

Prather Randall S, Wells Kevin D, Whitworth Kristin M, Kerrigan Maureen A, Samuel Melissa S, Mileham Alan, Popescu Luca N, Rowland Raymond R R

Abstract excerpt

After infection of the porcine dam at about 90 days of gestation, porcine reproductive and respiratory syndrome virus (PRRSV) crosses the placenta and begins to infect fetuses. Outcomes of include abortion, fetal death and respiratory disease in newborn piglets. CD163 is the receptor for the virus. In this study, CD163-positive fetuses, recovered between 109 days of gestation or 20 days after maternal infection,...

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Topics

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Share to Antigens, CD
Share to Antigens, Differentiation, Myelomonocytic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CD163 Antigen

Share to Gene Knockout Techniques

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Share to Receptors, Cell Surface

Source

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Identifiers

PMID: 29042674
DOI: 10.1038/s41598-017-13794-2
PMCID: PMC5645351

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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