Article
CsrA maximizes expression of the AcrAB multidrug resistance transporter.
Nucleic acids research - 15 Dec 2017
Ricci Vito, Attah Victoria, Overton Tim, Grainger David C, Piddock Laura J V
Abstract excerpt
Carbon Storage Regulator A (CsrA) is an RNA binding protein that acts as a global regulator of diverse genes. Using a combination of genetics and biochemistry we show that CsrA binds directly to the 5' end of the transcript encoding AcrAB. Deletion of csrA or mutagenesis of the CsrA binding sites reduced production of both AcrA and AcrB. Nucleotide substitutions at the 5' UTR of acrA mRNA that could potentially...
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