Small RNA Regulation of TolC, the Outer Membrane Component of Bacterial Multidrug Transporters.

doi:10.1128/JB.00971-15

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Article

Small RNA Regulation of TolC, the Outer Membrane Component of Bacterial Multidrug Transporters.

Journal of bacteriology - 25 Jan 2016

Parker Ashley, Gottesman Susan

Abstract excerpt

UNLABELLED: Bacteria use multidrug efflux pumps to export drugs and toxic compounds out of the cell. One of the most important efflux pumps in Escherichia coli is the AcrAB-TolC system. Small regulatory RNAs (sRNAs) are known to be major posttranscriptional regulators that can enhance or repress translation by binding to the 5' untranslated region (UTR) of mRNA targets with the help of a chaperone protein, Hfq....

Topics

Bacterial Outer Membrane Proteins
Biofilms
Carrier Proteins
Escherichia coli
Escherichia coli Proteins
Gene Expression Regulation, Bacterial
Membrane Transport Proteins
Mutation
RNA, Bacterial
RNA, Messenger

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Identifiers

PMID: 26811318
DOI: 10.1128/JB.00971-15
PMCID: PMC4800871

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