Article
Imputation of Baseline LDL Cholesterol Concentration in Patients with Familial Hypercholesterolemia on Statins or Ezetimibe.
Clinical chemistry - 1 Feb 2018
Ruel Isabelle, Aljenedil Sumayah, Sadri Iman, de Varennes Émilie, Hegele Robert A, Couture Patrick, Bergeron Jean, Wanneh Eric, Baass Alexis, Dufour Robert, Gaudet Daniel, Brisson Diane, Brunham Liam R, Francis Gordon A, Cermakova Lubomira, Brophy James M, Ryomoto Arnold, Mancini G B John, Genest Jacques
Abstract excerpt
BACKGROUND: Familial hypercholesterolemia (FH) is the most frequent genetic disorder seen clinically and is characterized by increased LDL cholesterol (LDL-C) (>95th percentile), family history of increased LDL-C, premature atherosclerotic cardiovascular disease (ASCVD) in the patient or in first-degree relatives, presence of tendinous xanthomas or premature corneal arcus, or presence of a pathogenic mutation in...
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