Article
Distinct Mechanisms of Phenotypic Effects of Inactivation and Prionization of Swi1 Protein in Saccharomyces cerevisiae.
Biochemistry. Biokhimiia - 1 Oct 2017
Antonets K S, Kliver S F, Polev D E, Shuvalova A R, Andreeva E A, Inge-Vechtomov S G, Nizhnikov A A
Abstract excerpt
Prions are proteins that under the same conditions can exist in two or more conformations, and at least one of the conformations has infectious properties. The prionization of a protein is typically accompanied by its functional inactivation due to sequestration of monomers by the prion aggregates. The most of prions has been identified in the yeast Saccharomyces cerevisiae. One of them is [SWI+], a prion isoform...
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