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Article

Distinct subregions of Swi1 manifest striking differences in prion transmission and SWI/SNF function.

Molecular and cellular biology - 1 Oct 2010

Du Zhiqiang, Crow Emily T, Kang Hyun Seok, Li Liming

Abstract excerpt

We have recently reported that the yeast chromatin-remodeling factor Swi1 can exist as a prion, [SWI(+)], demonstrating a link between prionogenesis and global transcriptional regulation. To shed light on how the Swi1 conformational switch influences Swi1 function and to define the sequence and structural requirements for [SWI(+)] formation and propagation, we functionally dissected the Swi1 molecule. We show...

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Identifiers

PMID: 20679490
DOI: 10.1128/MCB.00225-10
PMCID: PMC2950522

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