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Article

Porcn-dependent Wnt signaling is not required prior to mouse gastrulation

12 Jun 2013

Abstract excerpt

In mice and humans the X-chromosomal porcupine homolog (Porcn) gene is required for the acylation and secretion of all 19 Wnt ligands and thus represents a bottleneck for all Wnt signaling. We have generated a mouse line carrying a floxed allele for Porcn and used zygotic, oocyte-specific and visceral endoderm-specific deletions to investigate embryonic and extra-embryonic requirements for Wnt ligand secretion....

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Identifiers

PMID: 23760955
DOI: 10.1242/dev.094458

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Porcn-dependent Wnt signaling is not required prior to mouse gastrulationPMID 23760955Read ↗

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