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Article

Multi-omics phenotyping of the gut-liver axis reveals metabolic perturbations from a low-dose pesticide mixture in rats.

Communications biology - 14 Apr 2021

Mesnage Robin, Teixeira Maxime, Mandrioli Daniele, Falcioni Laura, Ibragim Mariam, Ducarmon Quinten Raymond, Zwittink Romy Daniëlle, Amiel Caroline, Panoff Jean-Michel, Bourne Emma, Savage Emanuel, Mein Charles A, Belpoggi Fiorella, Antoniou Michael N

Abstract excerpt

Health effects of pesticides are not always accurately detected using the current battery of regulatory toxicity tests. We compared standard histopathology and serum biochemistry measures and multi-omics analyses in a subchronic toxicity test of a mixture of six pesticides frequently detected in foodstuffs (azoxystrobin, boscalid, chlorpyrifos, glyphosate, imidacloprid and thiabendazole) in Sprague-Dawley rats....

Topics

Animals
Dose-Response Relationship, Drug
Female
Gastrointestinal Tract
Liver
Metabolomics
Pesticides
Phenotype
Rats
Rats, Sprague-Dawley

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33854195
DOI: 10.1038/s42003-021-01990-w
PMCID: PMC8046807

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