Article
IL-1 Family Cytokines Use Distinct Molecular Mechanisms to Signal through Their Shared Co-receptor.
Immunity - 19 Sept 2017
Günther Sebastian, Deredge Daniel, Bowers Amanda L, Luchini Alessandra, Bonsor Daniel A, Beadenkopf Robert, Liotta Lance, Wintrode Patrick L, Sundberg Eric J
Abstract excerpt
Within the interleukin 1 (IL-1) cytokine family, IL-1 receptor accessory protein (IL-1RAcP) is the co-receptor for eight receptor-cytokine pairs, including those involving cytokines IL-1β and IL-33. Unlike IL-1β, IL-33 does not have a signaling complex that includes both its cognate receptor, ST2, and the shared co-receptor IL-1RAcP, which we now present here. Although the IL-1β and IL-33 complexes shared...
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