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Functional variants in the low-density lipoprotein receptor gene are associated with clear cell renal cell carcinoma susceptibility.

Carcinogenesis - 7 Dec 2017

Zhang Gui-Ming, Wang Meng-Yun, Liu Ya-Nan, Zhu Yao, Wan Fang-Ning, Wei Qing-Yi, Ye Ding-Wei

Abstract excerpt

Recent studies indicate that abnormal levels of low-density lipoprotein (LDL), which is an important component of dyslipidaemia, are associated with alterations to cancer risk, including that of renal cell carcinoma (RCC). Single nucleotide polymorphisms at microRNA-binding sites contribute to cancer susceptibility and progression by affecting the messenger RNA (mRNA) function of target genes. In this...

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PMID: 29029037
DOI: 10.1093/carcin/bgx098

Genes

LDLR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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